Trans-synaptic Adhesions between Netrin-G Ligand-3 (NGL-3) and Receptor Tyrosine Phosphatases LAR, Protein-tyrosine Phosphatase (PTP ), and PTP via Specific Domains Regulate Excitatory Synapse Formation*
نویسندگان
چکیده
Seok-Kyu Kwon, Jooyeon Woo, Soo-Young Kim, Hyun Kim, and Eunjoon Kim From the National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, and Department of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon 305-701 and the Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, 126-1, 5-Ka, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea
منابع مشابه
Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
The initial contact between axons and dendrites at early neuronal synapses is mediated by surface adhesion molecules and is thought to induce synaptic maturation through the recruitment of additional synaptic proteins. The initiation of synaptic maturation should be tightly regulated to ensure that synaptic maturation occurs selectively at subcellular sites of axo-dendritic adhesion. However, t...
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Long-term depression (LTD) reduces the functional strength of excitatory synapses through mechanisms that include the removal of AMPA glutamate receptors from the postsynaptic membrane. LTD induction is also known to result in structural changes at excitatory synapses, including the shrinkage of dendritic spines. Synaptic adhesion molecules are thought to contribute to the development, function...
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Receptor protein tyrosine phosphatases include the leukocyte-common antigen related (LAR) family of cell adhesion molecules. In Caenorhabditis elegans, the LAR-like gene ptp-3 encodes two distinct isoforms, PTP-3A and PTP-3B. Compared with PTP-3A, the extracellular domain of PTP-3B lacks the Ig-like domain and the first four fibronectin type III repeats, but their intracellular domains are iden...
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Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LA...
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Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RP...
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